i have been taking mexi for about 10 yrs now.....if I miss a dose the difference is amazing stillness increases quickly, the most important thing that i find is to not skip a dose, it seems like there is a saturation period (in me anyway) I have not had any side effects either. I also go to the gym 5 times a week and also play soccer and find that creatine shortens the warm up process.

hope this helps
John

Type of Myotonia: johnrobia@hotmail.com,3

I've been taking Mexilitene for about 6 years now. Unfortunately it has become less potent over the years. I remember when I first took it; it was absolutely amazing. The symptoms of Myotonia Congenita were virtually gone. I'm currently on 2 250mg pills a day. If I increase it I feel a bit weird....and disoriented. With it becoming less effective I think it might be time for me to try something else. Any suggestions?

I am 42 and have been using mexiletine for about 2 years. I have not noticed it becoming less effective. Before mexiletine I used a similar sodium channel blocker (tonocard) for about 10 years. Sometimes I thought the tonocard had become less effective but I am not sure what the explanation would be for a drug to become less effective after many years of using it. It would make sense that a tolerance would be developed much sooner than that. Anyway I hope the effectiveness of mexiletine does not decrease over time. So far it has not.

I don't take any medication, but I have variances in stiffness too. Sometimes because I haven't stretched enough after exercise, and other times I just can't explain it. I tend to eat much the same food, so wonder if it's hormones or something in the air!

there are many different factors that contribute to my stiffness, change of seasons, stress, lack of sleep, lack of exercise and so on....somedays I feel that the mexi does not work as effective but I don't think it is the mexi it is life, even if you don't have MC you have bad days and good days but I do find the lazier I am the worse it gets so proper stretching and exercise are essential along with proper diet and sleep.....and if you think about it it is the same for anybody with or with out MC...keep a positive attitude and understand just how special we are

John

Type of Myotonia: johnrobia@hotmail.com,3

Hi everyone, i have a few questions about myotonia that i need some help with.. First here's my story.. I am 16 years old and was diagnosed with myotonia congenita 2 years ago, the doctors(neurologist) I went to at a muscular distrophy center had never heard of if before, but they did some research and declared thats what I had.They gave me some muscle relaxers but those didn't do a thing except make me dead tired. After that I kind of gave up on fixing "it" and just dealt with it, now that i have started searching more about myotonia i see that there are some things you can do. I know there are some different types of myotonia and I am wondering what type I have. Here are some problems that occur with me the most... I dont have myotonia as bad as some people do when they choke and stuff, but heres what happens to me.. the worst is when it gets really really hot and i start excercising, then take a little brake, and start exercising again.. it feels like im in slow motion and takes me a while to get going like normal.... For instance i went out for track last year and the first thing we did everyday was run 2 laps on the track, then start our regular practice. The myotonia didnt affect me unless we stopped running for more then 15 seconds, then my muscles would "lock up", then id kick my legs out trying to loosen my muscles up but it didnt help much...
so i'm wondering if this is the type of myotonia everyone else has and does mexitil help with this??? i also have been following Jan's diet for the last week and it has greatly improved, ive been mostly eating pizza and drinking milk and gatorade, for example, i ran 2 miles last night on the treadmill and when i finished i sat down for 5 minutes, then got up and ran again, and it didnt take me as long as usual to "get going again"...... Ive also heard that the reason for my myotonia is a potassium inbalance.. any ideas or comments??
THANKS FOR TAKING YOUR TIME TO READ THIS......

Type of Myotonia: ,3

Those are the typical symptoms. I have never choked or had trouble swallowing. But sounds like I have myotonia worse than you. After excercising and resting for a while it is worse than usual. From what I understand this drug Mexiteline (sp) really helps.